Fisetin C15H10O6

Senescent cells, often termed 'zombie cells,' are aged cells that disrupt surrounding tissues by ceasing to function properly. These cells, responsible for harmful inflammatory processes, are a major factor in age-related diseases. Senolytics, like fisetin, destroy these senescent cells, paving the way for effective anti-aging and disease-fighting strategies. More potent than quercetin, another senolytic, fisetin has demonstrated its effectiveness in eliminating approximately 70% of senescent cells without harming healthy cells. These findings suggest that fisetin could be the secret weapon in the fight against aging.

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As an antioxidant and anti-inflammatory agent, fisetin provides protection against oxidative stress and chronic inflammation. By neutralizing free radicals, it prevents potential damage to DNA, proteins, and other cellular components. Additionally, by reducing inflammation, fisetin blocks pathways that promote these processes and decreases the production of pro-inflammatory compounds

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Research has shown that caloric restriction slows aging, prolongs life, and enhances resistance to diseases. Fisetin mimics these beneficial effects by acting on several cellular pathways similar to those affected by caloric restriction. By stimulating sirtuins and AMPK proteins, fisetin promotes cellular health, regulates metabolism, and encourages autophagy, cellular "clean-up." These effects contribute to keeping cells on a youthful and healthy path

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In addition to its effects on longevity, fisetin offers remarkable protection against heart diseases, a leading cause of death. Recent studies have demonstrated its ability to shield the heart against damage, even after heart attack models. Cardiac cells benefit from fisetin's presence, preserving better heart function and reducing the extent of heart damage

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Fisetin also proves valuable in preventing obesity and metabolic disorders, such as type II diabetes. By acting on AMPK activity and mTOR, fisetin helps reduce weight gain and protects against associated disorders. Even in conditions of a high-fat diet, fisetin prevents weight gain while preserving the health of the liver, heart, and other organs. Murine models of diabetes show that fisetin improves blood sugar control and insulin sensitivity, offering a potential solution to elevated glucose levels

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Finally, fisetin also shines in its cognitive benefits. Animal studies have demonstrated its neuroprotective action in conditions such as Alzheimer's disease, Parkinson's disease, and ALS. Furthermore, clinical trials have shown its effectiveness in stroke treatment, extending the treatment window and preserving brain function

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